I've made a few changes from my original set up.
1. New saddle: Selle San Marco Aspide Glamor, which is a womens saddle, but the 155mm width is perfect for me. It's not the most comfortable saddle I've ridden but it's the most pain free and works great for me on rides of 4+ hours.
2. New wheels: M
Here is my Curtlo road bike. Aside from the custom tubing and geometry it has 135mm rear drop outs so I can run MTB hubs and Avid disc brakes (I'm a big guy). Other components include Ultegra 10 speed components, FSA Energy cranks and Ritchey stem/bar.