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The two methods work different body systems:

1.) High cadence works cardio
2.) Low cadence works muscles

You will need to build both systems.

Low cadence, seated climbs will help you with overall ability to generate power. This will help you push a big gear on the flats too. When doing low cadence, seated climbs you should target about 60 rpm. If you drop to 50 rpm downshift to an easier gear. Hard efforts at a real low cadence can hurt your knees.
 
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