Last bike I'll ever need (not the same as WANT...)
Just turned 59, 6'4", tragically hovering close to 250 (got an excuse, though: a family emergency has had me driving 600 extra miles a week to help out, so I pretty much spent the winter sitting in my car or eating fast food). Headed back down to <220 pounds.
Only about 50 miles a week now, plus a couple of hours on the trainer. Going to 125+ as soon as it's light enough to commute, with a century planned in May.
Got several bikes, but here's the main ride:
Atlantis frame
Mid-range Shimano ders. (Deore XT & LX)
Sugino XD crankset, 46-36-26 (everybody needs one)
I had 36-spoke Bontrager Fairlane rims w/XT hubs (what Rivendell puts on Atlantises it builds), but the spokes pulled out of the back rim at about 1500 miles. Riv offered a replacement at a great price, but I didn't see much point in doing the same thing again. LBS laced a Rhyno Lite to the same hub, no probs so far). 14ga. Wheelsmith spokes, three-cross front and back. Could be lighter, but I'm a big guy and the roads around here are rough.
Panaracer Pasela TG tires, 700x35 or x32 (true measurement is about 5mm skinnier; I love 'em).
Brooks B-17 saddle, Nitto long-quill stem to get the 50cm (!) Nashbar handlebars up level with the seat.
I've had this stuff about three years, around 4000 miles on this bike, and had no problems at all except for the back wheel. The wide bars are really nice--I'd recommend 48s or 50s to anybody my size.
Also got an old CDale mountain bike w/Rock Shox, otherwise stock, a lugged steel Allez w/mountain bike stem and 48cm bars and a singlespeed I built out of a Trek tourer. Everything edges toward durability rather than low weight, and hardly anything every breaks.