Tried 2 out of 3
I'd really want a top end groupo if spending that kind of money so wouldn't get a Litespeed when only Ultegra spec- especially as you are looking at alternative highend frames which allow you to access top end Duraace groupos.
Personally, I had a 2003 Giant TCR Comp 0. No fuss choice. Very reliable- no hassles after 2 years and 7000+ kms. Best thing was it got me out and riding. Worse thing was general lack of cred from peleton although must say that is changing. Only real issues were fork was a little soft for my 90kgs so cornering not so good and sizing difficult (L fraction small and XL fraction too big).
Now have a 2006 Trek 5.9SL. Has got me riding even more. ~5000km in under 8months. Best improvements over Giant for me were: Stiffer fork gives much better cornering. Tighter sizing options make much better bike fit (heaps more comfortable and power transfer yielded immediate increase in speed- professional bike fit helped here alot). Andromeda paint job with Ti anodised rims and hubs look gorgeous- get lots of comments. Worse things are: Trek exercised its right to change the bike spec on delivery and downgraded the seat post (check carefully on delivery cause they aren't interested after that). Reliability not good as Giant- Bonty low spoke count wheels already need to be trued (Ksyrium SL's didn't over more kms) and my RHS drop out/chain stay join has just failed- am taking it to the shop for a warranty claim this week (hopefully they will honour it).
Overall I still prefer the Trek (admittedly the join failure is a BIG issue but I haven;t heard of this often and I am hoping Trek will honour their warranty- one of my reasons for buying Trek is their lifetime warranty on frames so I am hoping this is actually a plus rather than a minus). Ultimately, better fit and handling means much more enjoyable cycling provided there is reasonable reliability which there seems to be (I'll repost if this doesn't end up being the case). Oh, and one other small thing, if the 5.9SL is good enough for a fair few pros to win stages and tours on it, who am I to argue when the bike has performed well enough for them?
Let us know your pick
