Cycling induced anoesis
+1. Also, you don't provide a history of how long you've been road riding or how long you've experienced the discomfort, but considering you've made adjustments to the saddle and cleat positions, you might want to consider a fitting. Even if you've had one, with those changes you may have complicated your issue and a fitting might get you back to a good (or at least, better) starting point.Kerry Irons said:Two things: 1) you're probably riding in too big a gear and 2) you (like the rest of us) are not applying the same force with both legs. Work on increasing your cadence and developing a smooth pedaling style.