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In my own experience, using the new pull ratio calipers with the older pull ratio STI shifters will give slightly less modulation, but more actual power/leverage. Another way to say that is the you'll have more power over the same amount of lever travel.
I ran a bike this way when I was in the middle of upgrading a few years back. I had 7900 brakes with 6600 shifters. The shifters were the same pull ratio as your current 105 brakes, but the calipers were the newer design. Being a heavier rider, I really liked the extra leverage and didn't even notice the tighter resolution. Braking with one finger became second nature on even the nastiest descents.
 
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