Yes, so long as your crank and chainstay do not impede release. You may want to stick to Zeros so you can limit float to the inside (which makes the pedals release with less rotation). You also may want to place your cleat on your shoes so the shoes are a little heel-out in relation to the cleat. This will make release to the inside easier(but release to the outside will require more rotation). I'm sure Speedplay would not recommend it.
Speedplays would NOT release to the inside for many years, so things must have changed. I'm not entirely convinced that they are now designed to release to the inside, but am willing to accept any kind of documentation on that.
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