53-39-28 x 12-13-14-15-16-17-18-19-21-23 10 cogs has the same range as 50-34x11-32 but no 15 17 or even 17 19 gap.I'd like to have 12sp cassettes and double front chain rings. Single front chain ring, no. With only 12 gears there's either not enough range or the gaps between some of the ratios are too wide.
But since I do a lot of extreme climbing rides/races I need a wider range of gearing than many road riders. I could use a 50/34 and 11-32 for some events, though a 34x28 is plenty for most of the riding I do. Even with the 11-28, a 12 cog cassette could provide the 16t to fill in the gap between the 15t and 17t.
Shux, with carbon fiber technology a, I guess it would be called, reverse parabolic wheel should be able to be built with the ability to run a freehub body at least to the center of the hub. That would have to be good for 16 cogs or maybe more.I'm sure that they'll come out with a 12 speed road group that you will again have to buy new wheels for (a 10 tooth cog won't fit on a standard freehub)..
I wonder if they will sell a 10-21 cassette to go with your 54/44 crank.